Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

Alessandro Bitto; Chad Lerner; Claudio Torres; Michaela Roell; Marco Malaguti; Viviana Perez; Antonello Lorenzini; Silvana Hrelia; Yuji Ikeno; Michelle Elizabeth Matzko; Roger McCarter; Christian Sell

doi:10.1371/journal.pone.0012592

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Open Access

Peer-reviewed

Research Article

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

Alessandro Bitto,

Affiliation Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Chad Lerner,

Affiliation Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Claudio Torres,

Affiliation Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michaela Roell,

Affiliation Department of Biochemistry, “G. Moruzzi” University of Bologna, Bologna, Italy
⨯
Marco Malaguti,

Affiliation Department of Biochemistry, “G. Moruzzi” University of Bologna, Bologna, Italy
⨯
Viviana Perez,

Affiliation Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Antonello Lorenzini,

Affiliations Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biochemistry, “G. Moruzzi” University of Bologna, Bologna, Italy
⨯
Silvana Hrelia,

Affiliation Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Yuji Ikeno,

Affiliation Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, Research Service, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas, United States of America
⨯
Michelle Elizabeth Matzko,

Affiliation Department of Biobehavioral Health, Penn State University, State College, Pennsylvania, United States of America
⨯
Roger McCarter,

Affiliation Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, Research Service, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas, United States of America
⨯
Christian Sell

* E-mail: christian.sell@drexelmed.edu

Affiliation Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

Alessandro Bitto,
Chad Lerner,
Claudio Torres,
Michaela Roell,
Marco Malaguti,
Viviana Perez,
Antonello Lorenzini,
Silvana Hrelia,
Yuji Ikeno,
Michelle Elizabeth Matzko

Published: September 7, 2010
https://doi.org/10.1371/journal.pone.0012592

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Author contribution

Posted by ChristianSell on 11 Sep 2010 at 14:48 GMT

We would like to acknowledge that the first 2 authors of this work made an equal contribution.

No competing interests declared.

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Mitochondria
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Autophagic cell death
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Fibroblasts
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Cell staining
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Mitochondrial DNA
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Growth factors
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Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

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Author contribution

Posted by ChristianSell on 11 Sep 2010 at 14:48 GMT