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closeComment from the editor
Posted by Deleted_Account on 18 May 2013 at 11:54 GMT
This manuscript supplies new genomic data leading to the creation of a new tailed phage genus - I hope the authors will continue detailed functional and structural studies of the phage and its proteins. The work may also have medical importance for the future, as the host of the described phage, Pseudomonas aeruginosa, is a major cause of opportunistic infections in humans, is naturally resistant to many antibiotics and can acquire resistance to more.
RE: Comment from the editor
hufuquan replied to Deleted_Account on 19 May 2013 at 03:20 GMT
Dear Dr. Mark J van Raaij, thanks very much for your good comments on this work. We are now trying to study the functions of some of PaP1 proteins, and PaP1 capsid and DNA packaging mechanisms. Surely the phage therapy attempts of PaP1 should be very important, although it is not an easy thing.