An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice

Paromita Bag; Durbadal Ojha; Hemanta Mukherjee; Umesh Chandra Halder; Supriya Mondal; Nidhi S. Chandra; Suman Nandi; Ashoke Sharon; Mamta Chawla Sarkar; Sekhar Chakrabarti; Debprasad Chattopadhyay

doi:10.1371/journal.pone.0077937

Loading metrics

Open Access

Peer-reviewed

Research Article

An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice

Paromita Bag,

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯
Durbadal Ojha,

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯
Hemanta Mukherjee,

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯
Umesh Chandra Halder,

Affiliation National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
⨯
Supriya Mondal,

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯
Nidhi S. Chandra,

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯
Suman Nandi,

Affiliation National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
⨯
Ashoke Sharon,

Affiliation Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, India
⨯
Mamta Chawla Sarkar,

Affiliation National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
⨯
Sekhar Chakrabarti,

Affiliations ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India, National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
⨯
Debprasad Chattopadhyay

* E-mail: debprasadc@yahoo.co.in

Affiliation ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India
⨯

An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice

Paromita Bag,
Durbadal Ojha,
Hemanta Mukherjee,
Umesh Chandra Halder,
Supriya Mondal,
Nidhi S. Chandra,
Suman Nandi,
Ashoke Sharon,
Mamta Chawla Sarkar,
Sekhar Chakrabarti

Published: October 22, 2013
https://doi.org/10.1371/journal.pone.0077937

Reader Comments

Post a new comment on this article

HM is Harmaline

Posted by LSchang on 07 Mar 2014 at 23:26 GMT

As far as I can see, 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole, the compound referred to as HM through the manuscript actually is harmaline, a psychoactive drug (a MAO inhibitor). Please indicate if there is any actual chemical differences between the compound referred to as HM through the manuscript and the previously known harmaline.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Vero cells
Is the Subject Area "Vero cells" applicable to this article?

Thanks for your feedback.
Ointments
Is the Subject Area "Ointments" applicable to this article?

Thanks for your feedback.
Herpes simplex virus-2
Is the Subject Area "Herpes simplex virus-2" applicable to this article?

Thanks for your feedback.
Virus testing
Is the Subject Area "Virus testing" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Antiviral therapy
Is the Subject Area "Antiviral therapy" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.

An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice

An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

HM is Harmaline

Posted by LSchang on 07 Mar 2014 at 23:26 GMT