Reader Comments

Post a new comment on this article

New evidence for a role of PrPC as modulator of innate immunity signaling

Posted by loma on 09 Jan 2018 at 10:16 GMT

In J Neuroinflammation 2017, 14:106 and Front Immunol. 2017, 8: 1722, Salvesen et al. provide evidence for the down-regulation of innate immunity signaling by PrPC in an animal model of systemic LPS challenge of goat. Their observations are very reminiscent of the PrPC-dependent down-regulation of immune-activated retroviruses in mice, as reported here. Immune-activated retroviruses may well be PrPC-controlled mediators of innate immunity signaling, in mice as well as in goats.

No competing interests declared.