Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

Harald Staiger; Fausto Machicao; Konstantinos Kantartzis; Silke A. Schäfer; Kerstin Kirchhoff; Martina Guthoff; Günther Silbernagel; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring

doi:10.1371/journal.pone.0003019

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Peer-reviewed

Research Article

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

Harald Staiger ,

* E-mail: harald.staiger@med.uni-tuebingen.de

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Fausto Machicao,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Konstantinos Kantartzis,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Silke A. Schäfer,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Kerstin Kirchhoff,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Martina Guthoff,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Günther Silbernagel,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Norbert Stefan,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Andreas Fritsche,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Hans-Ulrich Häring

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

Harald Staiger,
Fausto Machicao,
Konstantinos Kantartzis,
Silke A. Schäfer,
Kerstin Kirchhoff,
Martina Guthoff,
Günther Silbernagel,
Norbert Stefan,
Andreas Fritsche,
Hans-Ulrich Häring

Published: August 20, 2008
https://doi.org/10.1371/journal.pone.0003019

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C-peptide to support association - a comment

Posted by ntkrarup on 21 Aug 2008 at 07:27 GMT

Dear H. Staiger and coworkers.
We have with interest read your work on the novel Type 2 Diabetes risk loci, which strengthens our findings earlier this year. In that study we didn't include measurements of C-peptide in the results section but we would like to stress that analysis of C-peptide data showed similar results as for serum insulin; both regarding the negative as well as the positive associations with measures of insulin secretion.
We hope that this additional information is of use.

Best regards,
MD Niels Grarup
MB Nikolaj T. Krarup

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Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

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C-peptide to support association - a comment

Posted by ntkrarup on 21 Aug 2008 at 07:27 GMT