Chimeric β-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions

Christopher M. Clouthier; Sébastien Morin; Sophie M. C. Gobeil; Nicolas Doucet; Jonathan Blanchet; Elisabeth Nguyen; Stéphane M. Gagné; Joelle N. Pelletier

doi:10.1371/journal.pone.0052283

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Research Article

Chimeric β-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions

Christopher M. Clouthier,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Chimie, Université de Montréal, Montréal, Québec, Canada
⨯
Sébastien Morin,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Biochimie, Microbiologie et Bioinformatique, Université Laval, Laval Québec, Canada
⨯
Sophie M. C. Gobeil,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Biochimie, Université de Montréal, Montréal, Québec, Canada
⨯
Nicolas Doucet,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, INRS–Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada
⨯
Jonathan Blanchet,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Chimie, Université de Montréal, Montréal, Québec, Canada
⨯
Elisabeth Nguyen,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Chimie, Université de Montréal, Montréal, Québec, Canada
⨯
Stéphane M. Gagné,

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Biochimie, Microbiologie et Bioinformatique, Université Laval, Laval Québec, Canada
⨯
Joelle N. Pelletier

* E-mail: joelle.pelletier@umontreal.ca

Affiliations PROTEO, the Québec Network for Research on Protein Structure, Function and Engineering, Université Laval, Laval, Québec, Canada, Département de Chimie, Université de Montréal, Montréal, Québec, Canada, Département de Biochimie, Université de Montréal, Montréal, Québec, Canada
⨯

Chimeric β-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions

Christopher M. Clouthier,
Sébastien Morin,
Sophie M. C. Gobeil,
Nicolas Doucet,
Jonathan Blanchet,
Elisabeth Nguyen,
Stéphane M. Gagné,
Joelle N. Pelletier

Published: December 21, 2012
https://doi.org/10.1371/journal.pone.0052283

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Perturbation of dynamics

Posted by salsbufr on 12 Mar 2013 at 19:32 GMT

This particular paper was especially interesting to me because they studied the response of motion to mutation; not just structure.

Competing interests declared: I was the PLoSOne editor for this paper.

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Chimeric β-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions

Chimeric β-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions

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Perturbation of dynamics

Posted by salsbufr on 12 Mar 2013 at 19:32 GMT