Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus

In O. Sun; Sung Hye Shin; A. Young Cho; Hyun Ju Yoon; Mi Yok Chang; Kwang Young Lee

doi:10.1371/journal.pone.0175890

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Research Article

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus

In O. Sun,

Affiliation Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
⨯
Sung Hye Shin,

Affiliation Christian Medical Research Center, Presbyterian Medical Center, Jeonju, Korea
⨯
A. Young Cho,

Affiliation Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
⨯
Hyun Ju Yoon,

Affiliation Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
⨯
Mi Yok Chang,

Affiliation Division of Infection, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
⨯
Kwang Young Lee

* E-mail: kwangpmc@hanmail.net

Affiliations Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea, Christian Medical Research Center, Presbyterian Medical Center, Jeonju, Korea

http://orcid.org/0000-0002-5754-1452

⨯

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus

In O. Sun,
Sung Hye Shin,
A. Young Cho,
Hyun Ju Yoon,
Mi Yok Chang,
Kwang Young Lee

Published: April 18, 2017
https://doi.org/10.1371/journal.pone.0175890

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Plasma or serum NGAL?

Posted by luttenthal on 23 Apr 2017 at 05:03 GMT

The authors describe the measurement of NGAL in EDTA-plasma samples but then refer to the results as "serum NGAL". This appears to be incorrect and potentially misleading, even if this imprecise terminology is quite common medical jargon. The matter is significant, because NGAL levels in EDTA-plasma are typically lower than in serum. EDTA inhibits the calcium-dependent release of NGAL from neutrophils during the preparation of plasma, whereas some additional NGAL is released from the neutrophils when preparing serum. Measuring NGAL in EDTA-plasma seeks minimize the contribution from neutrophilic inflammation, while serum NGAL values may reflect the NGAL released from both organs and neutrophils.

No competing interests declared.

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Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus

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Plasma or serum NGAL?

Posted by luttenthal on 23 Apr 2017 at 05:03 GMT