The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

Carlo Meneghini; Loris Leboffe; Monica Bionducci; Gabriella Fanali; Massimiliano Meli; Giorgio Colombo; Mauro Fasano; Paolo Ascenzi; Settimio Mobilio

doi:10.1371/journal.pone.0104231

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Research Article

The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

Carlo Meneghini ,

Contributed equally to this work with: Carlo Meneghini, Loris Leboffe

Affiliation Department of Sciences, Roma Tre University, Roma, Italy
⨯
Loris Leboffe ,

Contributed equally to this work with: Carlo Meneghini, Loris Leboffe

Affiliations Department of Sciences, Roma Tre University, Roma, Italy, National Institute of Biostructures and Biosystems, Roma, Italy
⨯
Monica Bionducci,

Affiliation Department of Sciences, Roma Tre University, Roma, Italy
⨯
Gabriella Fanali,

Affiliation Biomedical Research Division, Department of Theoretical and Applied Sciences, and Center of Neuroscience, University of Insubria, Busto Arsizio (VA), Italy
⨯
Massimiliano Meli,

Affiliation Institute for Molecular Recognition Chemistry, National Research Council, Milano, Italy
⨯
Giorgio Colombo,

Affiliation Institute for Molecular Recognition Chemistry, National Research Council, Milano, Italy
⨯
Mauro Fasano,

Affiliation Biomedical Research Division, Department of Theoretical and Applied Sciences, and Center of Neuroscience, University of Insubria, Busto Arsizio (VA), Italy
⨯
Paolo Ascenzi ,

* E-mail: ascenzi@uniroma3.it

Affiliations National Institute of Biostructures and Biosystems, Roma, Italy, Interdepartmental Laboratory of Electron Microscopy, Roma Tre University, Roma, Italy
⨯
Settimio Mobilio

Affiliation Department of Sciences, Roma Tre University, Roma, Italy
⨯

The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

Carlo Meneghini,
Loris Leboffe,
Monica Bionducci,
Gabriella Fanali,
Massimiliano Meli,
Giorgio Colombo,
Mauro Fasano,
Paolo Ascenzi,
Settimio Mobilio

Published: August 25, 2014
https://doi.org/10.1371/journal.pone.0104231

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Figure 5 of the paper entitled "The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study" is wrong

Posted by pascenzi on 10 Sep 2014 at 15:11 GMT

We apologize for publishing the wrong version of Figure 5. The corrected Figure 5 has been submitted to the Editor.
The corrected Figure 5 does not affect the content and the scope of the paper. Indeed, only the shape but not the geometry of the His146 residue in panels B and C has been corrected. Moreover, neither the legend of the corrected Figure 5 nor the manuscript text have been changed.
To obtain the corrected Figure 5, the reader can contact the corresponding author Prof. Paolo Ascenzi (e-mail: ascenzi@uniroma3.it).

No competing interests declared.

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The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

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Figure 5 of the paper entitled "The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study" is wrong

Posted by pascenzi on 10 Sep 2014 at 15:11 GMT