SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells

Marcos Francia; Martin Stortz; Camila Vazquez Echegaray; Camila Oses; Paula Verneri; María Victoria Petrone; Ayelen Toro; Ariel Waisman; Santiago Miriuka; María Soledad Cosentino; Valeria Levi; Alejandra Guberman

doi:10.1371/journal.pone.0254447

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Open Access

Peer-reviewed

Research Article

SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells

Marcos Francia,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

https://orcid.org/0000-0002-9719-8249

⨯
Martin Stortz,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Camila Vazquez Echegaray,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Camila Oses,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Paula Verneri,

Roles Investigation, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
María Victoria Petrone,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Ayelen Toro,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Ariel Waisman,

Roles Conceptualization, Methodology, Resources, Supervision, Validation, Writing – review & editing

Affiliation Laboratorio de Investigación Aplicada a las Neurociencias Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (LIAN, FLENI-CONICET), Escobar, Provincia de Buenos Aires, Argentina
⨯
Santiago Miriuka,

Roles Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Laboratorio de Investigación Aplicada a las Neurociencias Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (LIAN, FLENI-CONICET), Escobar, Provincia de Buenos Aires, Argentina
⨯
María Soledad Cosentino,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Valeria Levi,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

Affiliation Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Alejandra Guberman

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: algub@qb.fcen.uba.ar

Affiliations Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN, CONICET-UBA), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina, Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

https://orcid.org/0000-0002-4291-6741

⨯

SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells

Marcos Francia,
Martin Stortz,
Camila Vazquez Echegaray,
Camila Oses,
Paula Verneri,
María Victoria Petrone,
Ayelen Toro,
Ariel Waisman,
Santiago Miriuka,
María Soledad Cosentino

Published: July 9, 2021
https://doi.org/10.1371/journal.pone.0254447

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Disclosure for the readers of this scientific paper:

Posted by mfrancia on 24 May 2022 at 17:20 GMT

The authors would like to advise that the Figure 2 legend is not properly positioned below the corresponding image, but instead is unintentionally placed as part of the text. This misplaced paragraph might slightly interrupt the fluency of the reading, especially in the PDF file.

No competing interests declared.

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SUMOylation
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SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells

SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells

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Disclosure for the readers of this scientific paper:

Posted by mfrancia on 24 May 2022 at 17:20 GMT