Genome-Wide Scan for Signatures of Human Population Differentiation and Their Relationship with Natural Selection, Functional Pathways and Diseases

Roberto Amato; Michele Pinelli; Antonella Monticelli; Davide Marino; Gennaro Miele; Sergio Cocozza

doi:10.1371/journal.pone.0007927

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Research Article

Genome-Wide Scan for Signatures of Human Population Differentiation and Their Relationship with Natural Selection, Functional Pathways and Diseases

Roberto Amato ,

* E-mail: roamato@na.infn.it

Affiliations Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli “Federico II” - Università di Salerno, Naples, Italy, Dipartimento di Scienze Fisiche, Università degli Studi di Napoli “Federico II”, Naples, Italy
⨯
Michele Pinelli,

Affiliations Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli “Federico II” - Università di Salerno, Naples, Italy, Dipartimento di Biologia e Patologia Cellulare e Molecolare “L. Califano”, Università degli Studi di Napoli “Federico II”, Naples, Italy
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Antonella Monticelli,

Affiliation Istituto di Endocrinologia ed Oncologia Sperimentale, CNR Napoli, Naples, Italy
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Davide Marino,

Affiliation Dipartimento di Scienze Fisiche, Università degli Studi di Napoli “Federico II”, Naples, Italy
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Gennaro Miele,

Affiliations Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli “Federico II” - Università di Salerno, Naples, Italy, Dipartimento di Scienze Fisiche, Università degli Studi di Napoli “Federico II”, Naples, Italy, Istituto Nazionale di Fisica Nucleare – Sezione di Napoli, Naples, Italy
⨯
Sergio Cocozza

Affiliations Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli “Federico II” - Università di Salerno, Naples, Italy, Dipartimento di Biologia e Patologia Cellulare e Molecolare “L. Califano”, Università degli Studi di Napoli “Federico II”, Naples, Italy
⨯

Genome-Wide Scan for Signatures of Human Population Differentiation and Their Relationship with Natural Selection, Functional Pathways and Diseases

Roberto Amato,
Michele Pinelli,
Antonella Monticelli,
Davide Marino,
Gennaro Miele,
Sergio Cocozza

Published: November 20, 2009
https://doi.org/10.1371/journal.pone.0007927

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Read carefully- not straightforward Fst here

Posted by dtae on 26 May 2010 at 15:43 GMT

Mean FST value of genes with and without interspecific evidence of positive selection.
http://plosone.org/article/info:doi/10.1371/journal.pone.0007927#pone-0007927-g003

As the authors note in the text, these Fst values are from "considering FST of a gene the maximum FST value in the gene region". This is important in that these high Fst values are not directly comparable to other Fst values genomewide, such at the often-cited 12.5% figure across human populations.

No competing interests declared.

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Single nucleotide polymorphisms
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Population genetics
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Genome-Wide Scan for Signatures of Human Population Differentiation and Their Relationship with Natural Selection, Functional Pathways and Diseases

Genome-Wide Scan for Signatures of Human Population Differentiation and Their Relationship with Natural Selection, Functional Pathways and Diseases

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Read carefully- not straightforward Fst here

Posted by dtae on 26 May 2010 at 15:43 GMT