A 60 year-long, well-established, clinical experience allows me to state that either ignoring or overlooking the real existence of Quantum Biophysical Semeiotic Constitutions, including those of CVD, T2DM, as well as Oncological Terrain (http://www.sisbq.org), and their related Inherited Real Risks, bedside evaluated in a quantitative way, and removed by inexpensive Quantum Therapy. Only knowing these inherited risks, we can correlate the deficiency of various substances with the onset of any disorder (1-6).
In fact, Authors around the world are thinking wrongly that all individuals may are born equal and thus may be involved, e.g., by cvd, diabetes mellitus and/or malignancy, and consequently all individuals have to undergo identical laboratory and Image Depatment investigations, as tumour biomarkers assessment, therefore spending uselessly NHS money, and causing Psychological Jatrogenetic Terrorism, physician's energy and time loss.
In addition, for instance, women can be involved by Oncological Terrain, even with or without precise location of cancer inherited real risk in a well defined breast quadrant ("ab posse ad esse non licet illatio", Kant, Kritik der reinigen Vernunft) (7).

Because a singular congenital functional mitochondrial cytopathology is mainly overlooked, that is tha "conditio sine qua non" of the most frequent and dangerous human disorders, including CVD, T2DM, and malignancies, current clinical researches are fundamentally biased.
In other words, it does not consider the existence or assess the seriousness as well as the location of Congenital Acidosic Enzyme-Metabolic Histangiopathy (1-7), conditio sine qua non of both Oncological Terrain and, consequently cancer "inherited real risk".
In fact, both environmental risk factors and every drug, including Vit D, suggested as inversely corrlated with above-mentioned disorders, "could" influence some human biological functions and/or bring about different disorders, such as CVD and cancer, exclusively in relation to both the presence and intensity of CAEMH, constitutions are based on, in a well-defined biological system, according to Mitochondrial Eteroplasmy.
For instance, despite either the well-known negative influence of Vit D deficinecy syndrome or the beneficial, positive effects of selective cyclooxygenase-2 (COX-2) inhibitors on breast oncogenesis (1), we have to consider the importance of the "genetic predispositions", for instance, Oncological Terrain, as far as the onset of a lot of disorders is concerned, including osteoporosis and breast cancer.
In conclusion, we need first of all (i.e., starting whatever screening or research) to investigate the presence and intensity of CAEMH in the tested population, i.e., in every, single patient to be enrolled, and soon thereafter assessing presence, intensity and location of the CAEMH, various Constitution-Dependent, Inherited Real Risks are based on. Really, e.g., without Oncological Terrain, i.e., gene alterations of psycho-neuro-endocrine-immunological system, oncogenesis is not possible, as allows me to state a 60-year-long clinical experience with Biophysical Semeiotics, Single Patient Based Medicine theory is based on (1,2). Interestingly, these pathological conditions are characterized by microcirculatory remodelling, wherein a central role is played by newborn-pathological, type I, subtype a) oncological, and b) aspecific, Endoarteriolar Blocking Devices (1-8).
The above mentioned advances in physical semeiotics will play a central role in the future pre-primary and primary prevention of the most common and severe disorders, which are today’s growing epidemics.

References

1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory....

2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory....
3) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009 http://www.athero.org/com...

4) Sergio Stagnaro and Simone Caramel (2012). Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment. Journal of Pharmacy and Nutrition Sciences, (27 June 2012) | doi:10.1038/ejcn.2012.76, http://www.lifescienceglo.... PMID:22739250 [Medline]
5) Stagnaro MN, Stagnaro S Early clinical diagnosis of osteoporosis using auscultatory percussion. Therapeutic monitoring. Clin Ter. 1991 Apr 15;137(1):21-7. [Medline]
6) Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter.;146(3):215-9 [Medline]
7) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or... [MEDLINE]
8) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.