A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

Hiroki Kagawa; Yuka Shino; Daigo Kobayashi; Syunsuke Demizu; Masumi Shimada; Hiroyoshi Ariga; Hiroyuki Kawahara

doi:10.1371/journal.pone.0018638

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Peer-reviewed

Research Article

A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

Hiroki Kagawa,

Affiliations Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan, Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Yuka Shino,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Daigo Kobayashi,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Syunsuke Demizu,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Masumi Shimada,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Hiroyoshi Ariga,

Affiliation Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
⨯
Hiroyuki Kawahara

* E-mail: hkawa@tmu.ac.jp

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯

A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

Hiroki Kagawa,
Yuka Shino,
Daigo Kobayashi,
Syunsuke Demizu,
Masumi Shimada,
Hiroyoshi Ariga,
Hiroyuki Kawahara

Published: April 13, 2011
https://doi.org/10.1371/journal.pone.0018638

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Nuclear Localisation

Posted by gwneill on 06 Oct 2011 at 16:21 GMT

I find this paper very interesting and it may help explain what appears to be nuclear localisation of PATCHED1 in sertoli cells that was detected with a C-terminal antibody but that wasn't really explained by the authors (Kogerman P et al, Oncogene 2002: Fig.4A).

No competing interests declared.

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A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

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Nuclear Localisation

Posted by gwneill on 06 Oct 2011 at 16:21 GMT