Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

Hongjie Wang; Yulan Jin; M. V. Prasad Linga Reddy; Robert Podolsky; Siyang Liu; Ping Yang; Bruce Bode; John Chip Reed; R. Dennis Steed; Stephen W. Anderson; Leigh Steed; Diane Hopkins; Yihua Huang; Jin-Xiong She

doi:10.1371/journal.pone.0011789

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Peer-reviewed

Research Article

Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

Hongjie Wang ,

Contributed equally to this work with: Hongjie Wang, Yulan Jin

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Yulan Jin ,

Contributed equally to this work with: Hongjie Wang, Yulan Jin

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
M. V. Prasad Linga Reddy,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Robert Podolsky,

Affiliations Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America, Department of Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Siyang Liu,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
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Ping Yang,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
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Bruce Bode,

Affiliation Atlanta Diabetes Associates, Atlanta, Georgia, United States of America
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John Chip Reed,

Affiliation Southeastern Endocrine and Diabetes, Atlanta, Georgia, United States of America
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R. Dennis Steed,

Affiliation Southeastern Endocrine and Diabetes, Atlanta, Georgia, United States of America
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Stephen W. Anderson,

Affiliation Pediatric Endocrine Associates, Atlanta, Georgia, United States of America
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Leigh Steed,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
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Diane Hopkins,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Yihua Huang,

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Jin-Xiong She

* E-mail: jshe@mail.mcg.edu

Affiliations Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America, Department of Pathology, Medical College of Georgia, Augusta, Georgia, United States of America
⨯

Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

Hongjie Wang,
Yulan Jin,
M. V. Prasad Linga Reddy,
Robert Podolsky,
Siyang Liu,
Ping Yang,
Bruce Bode,
John Chip Reed,
R. Dennis Steed,
Stephen W. Anderson

Published: July 26, 2010
https://doi.org/10.1371/journal.pone.0011789

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Author summary

Posted by sunshine72 on 27 Jul 2010 at 13:36 GMT

Type 1 diabetes (T1D) is an autoimmune disease resulting from the complex interaction between susceptibility genes and environmental factors. This disease has been used as a model system to elucidate the complex genetics involved in common diseases in the last 25 years. Despite the mapping of over 40 loci by genome-wide association studies, the specific genes and their underlying mechanisms of action remain largely elusive. Identification of ERBB3 as a gene involved in T1D and immune regulation significantly improves our understanding on how T1D susceptibility genes may interact with environmental triggers to predispose high risk subjects to the development of autoimmune diabetes.

No competing interests declared.

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Single nucleotide polymorphisms
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Antigen-presenting cells
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Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

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Author summary

Posted by sunshine72 on 27 Jul 2010 at 13:36 GMT