Nitric oxide is associated with fracture risk in Japanese women

Masataka Shiraki; Tatsuhiko Kuroda; Masaki Nakano; Yukio Nakamura; Mitsuru Saito; Tomohiko Urano

doi:10.1371/journal.pone.0280854

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Open Access

Peer-reviewed

Research Article

Nitric oxide is associated with fracture risk in Japanese women

Masataka Shiraki,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft

Affiliation Research Institute and Practice for Involutional Diseases, Azumino City, Nagano, Japan
⨯
Tatsuhiko Kuroda,

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation Public Health Research Foundation, Shinjuku-ku, Tokyo, Japan
⨯
Masaki Nakano,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto City, Nagano, Japan
⨯
Yukio Nakamura ,

Roles Investigation, Supervision, Validation, Writing – review & editing

* E-mail: yxn14@aol.jp

Affiliation Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto City, Nagano, Japan

https://orcid.org/0000-0002-3911-7180

⨯
Mitsuru Saito,

Roles Investigation, Supervision, Validation, Writing – review & editing

Affiliation Department of Orthopaedic Surgery, Jikei University School of Medicine, Minato-ku, Tokyo, Japan
⨯
Tomohiko Urano

Roles Investigation, Supervision, Validation, Writing – review & editing

Affiliation Department of Geriatric Medicine, International University of Health and Welfare School of Medicine, Narita City, Chiba, Japan
⨯

Nitric oxide is associated with fracture risk in Japanese women

Masataka Shiraki,
Tatsuhiko Kuroda,
Masaki Nakano,
Yukio Nakamura,
Mitsuru Saito,
Tomohiko Urano

Published: February 7, 2023
https://doi.org/10.1371/journal.pone.0280854

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Low nitric oxide could indicate low testosterone

Posted by jamesmhoward on 08 Feb 2023 at 09:26 GMT

I suggest the basis of the findings of Shiraki, et al., is low testosterone. It is known nitric oxide stimulates testosterone. Fracture risk is increased by low testosterone.

No competing interests declared.

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Bone fracture
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Nitric oxide
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Osteoporosis
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Nitric oxide is associated with fracture risk in Japanese women

Nitric oxide is associated with fracture risk in Japanese women

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Low nitric oxide could indicate low testosterone

Posted by jamesmhoward on 08 Feb 2023 at 09:26 GMT