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closeots167 off-target effects
Posted by dz118 on 28 Feb 2017 at 17:44 GMT
The authors write, "OTS167 at very high concentrations (10 μM) has been shown to decrease the activity of up to 210 kinases [59]." However, it does not appear that OTS167 was one of the compounds tested in the paper cited. Did the authors mean to cite a different study?
RE: ots167 off-target effects
CeciliaWilliams replied to dz118 on 25 Aug 2017 at 14:38 GMT
The reference for the test of the OTSSP167 compound should have been: Gray, Nathanael and Liu, Qingsong, KIN001-220 KINOMEscan, Data Set ID 20041, Harvard LINCS Kinome Scan, 2013-2015. (http://lincs.hms.harvard....). We apologize for the unintentional omission of this reference.
The paper cited by us (#59: Fabian MA et al., Nat Biotechnol. 2005, PMID: 15711537) referred to the protocol used in the above scan.
/Authors