A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

Hilary Gerstein; Rikki Hullinger; Mary J. Lindstrom; Corinna Burger

doi:10.1371/journal.pone.0062360

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Research Article

A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

Hilary Gerstein,

Affiliations Department of Neurology, University of Wisconsin-Madison, Medical Sciences Center, Madison, Wisconsin, United States of America, Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Rikki Hullinger,

Affiliation Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Mary J. Lindstrom,

Affiliation Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Corinna Burger

* E-mail: burger@neurology.wisc.edu

Affiliation Department of Neurology, University of Wisconsin-Madison, Medical Sciences Center, Madison, Wisconsin, United States of America
⨯

A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

Hilary Gerstein,
Rikki Hullinger,
Mary J. Lindstrom,
Corinna Burger

Published: May 7, 2013
https://doi.org/10.1371/journal.pone.0062360

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Figure 3 F

Posted by coburger on 23 May 2013 at 15:26 GMT

Table 3 shows the cross tabulation for the category assignments for OLM2 and MWM. Correlation analysis using the three groups of aged rats (SL, INT and AI) shows no statistical significance (n= 40, r = 0.24, p = 0.1418) (Figure 2F).

Table 3 shows the cross tabulation for the category assignments for OLM2 and MWM. Correlation analysis using the three groups of aged rats (SL, INT and AI) shows no statistical significance (n= 40, r = 0.24, p = 0.1418) (Figure 3F).

No competing interests declared.

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A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

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Figure 3 F

Posted by coburger on 23 May 2013 at 15:26 GMT