Interaction of the Anticancer Plant Alkaloid Sanguinarine with Bovine Serum Albumin

Maidul Hossain; Asma Yasmeen Khan; Gopinatha Suresh Kumar

doi:10.1371/journal.pone.0018333

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Research Article

Interaction of the Anticancer Plant Alkaloid Sanguinarine with Bovine Serum Albumin

Maidul Hossain ,

Contributed equally to this work with: Maidul Hossain, Asma Yasmeen Khan

Affiliation Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research (CSIR), Kolkata, West Bengal, India
⨯
Asma Yasmeen Khan ,

Contributed equally to this work with: Maidul Hossain, Asma Yasmeen Khan

Affiliation Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research (CSIR), Kolkata, West Bengal, India
⨯
Gopinatha Suresh Kumar

* E-mail: gskumar@iicb.res.in

Affiliation Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research (CSIR), Kolkata, West Bengal, India
⨯

Interaction of the Anticancer Plant Alkaloid Sanguinarine with Bovine Serum Albumin

Maidul Hossain,
Asma Yasmeen Khan,
Gopinatha Suresh Kumar

Published: April 6, 2011
https://doi.org/10.1371/journal.pone.0018333

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Binding stoichiometries much less than 1

Posted by mvdw on 08 Apr 2011 at 14:45 GMT

The number of binding sites for alkanolamine (0.197) was smaller compared to that for the iminium (0.298).
http://plosone.org/article/info:doi/10.1371/journal.pone.0018333#article1.body1.sec2.sec6.p1

I am surprised the authors do not discuss the calculated binding stoichiometry in more detail. The fact that only 1 alkanolamine binds per 5 BSA molecules is, to say the least, rather odd. What could be the cause of this?

No competing interests declared.

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Interaction of the Anticancer Plant Alkaloid Sanguinarine with Bovine Serum Albumin

Interaction of the Anticancer Plant Alkaloid Sanguinarine with Bovine Serum Albumin

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Binding stoichiometries much less than 1

Posted by mvdw on 08 Apr 2011 at 14:45 GMT