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résistance

Posted by benoit on 06 Feb 2008 at 15:24 GMT

is there spécifics treatment to kill staphylocoques into the macrophages .

RE: résistance

author replied to benoit on 12 Feb 2008 at 08:18 GMT

In the case of typical intracellular pathogens, there are some antibiotics known. These drugs have intracellular, bactericidal activity. But S.aureus appears to be resistant to most of them. The most difficult to kill intracellularly are SCV (small colony variants) strains. Furthermore, S.aureus, thanks to horizontal gene transfer, is able to obtain antibiotic resistance properties- so activity well defined antistaphylococcal antibiotics is somehow not sufficient. See also -Qazi et al. papers.