Identification, localization and expression of NHE isoforms in the alveolar epithelial cells

Safa Kinaneh; Yara Knany; Emad E. Khoury; Reem Ismael-Badarneh; Shadi Hamoud; Gidon Berger; Zaid Abassi; Zaher S. Azzam

doi:10.1371/journal.pone.0239240

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Open Access

Peer-reviewed

Research Article

Identification, localization and expression of NHE isoforms in the alveolar epithelial cells

Safa Kinaneh,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel
⨯
Yara Knany,

Roles Investigation, Writing – review & editing

Affiliation Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel
⨯
Emad E. Khoury,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel
⨯
Reem Ismael-Badarneh,

Roles Validation, Writing – review & editing

Affiliation Youth Center for Science, Ort Braude College of Engineering, Karmiel, Israel
⨯
Shadi Hamoud,

Roles Formal analysis, Writing – review & editing

Affiliations Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel, Internal Medicine “E”, Rambam: Human Health Care Campus, Haifa, Israel

https://orcid.org/0000-0003-1405-239X

⨯
Gidon Berger,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliations Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel, Internal Medicine “B”, Rambam: Human Health Care Campus, Haifa, Israel
⨯
Zaid Abassi,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel
⨯
Zaher S. Azzam

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: z_azzam@rambam.health.gov.il

Affiliations Ruth & Bruce Rappaport Faculty of Medicine, Department of Physiology, Technion, Israel Institute of Technology, Haifa, Israel, Internal Medicine “B”, Rambam: Human Health Care Campus, Haifa, Israel

https://orcid.org/0000-0001-7355-5400

⨯

Identification, localization and expression of NHE isoforms in the alveolar epithelial cells

Safa Kinaneh,
Yara Knany,
Emad E. Khoury,
Reem Ismael-Badarneh,
Shadi Hamoud,
Gidon Berger,
Zaid Abassi,
Zaher S. Azzam

Published: April 21, 2021
https://doi.org/10.1371/journal.pone.0239240

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Apical NHE physiological relevance in airway epithelia

Posted by tdantaspessoa on 16 Sep 2022 at 11:53 GMT

In the kidneys, NHE3 has the important role to absorb NaHCO3 (not sodium as you wrote in the introduction) and to generate new HCO3-. That is why in the kidney the mechanism to reabsorb sodium is coupled to H+ secretion: this is a mechanism to maintain the pH homeostasis, an essential Kidney function. On the other hand, in the airways formation of normal, detached mucus is dependent on bicarbonate. Lack of bicarbonate at mucus secretion in CF (cystic fibrosis) left the mucus more compact (...), thereby causing the attached CF mucus (Giorgetti, Melania et al. 2021). So why should the cell secrete H+ and acidify the mucus? It is difficult to me to find a reasonable physiological function for the apical expression of NHE. Maybe you (Authors) have some explanation to give to me.

No competing interests declared.

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Identification, localization and expression of NHE isoforms in the alveolar epithelial cells

Identification, localization and expression of NHE isoforms in the alveolar epithelial cells

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Apical NHE physiological relevance in airway epithelia

Posted by tdantaspessoa on 16 Sep 2022 at 11:53 GMT