Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

Uppoor G. Bhat; Marianna Halasi; Andrei L. Gartel

doi:10.1371/journal.pone.0005592

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Research Article

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

Uppoor G. Bhat,

Affiliation Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
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Marianna Halasi,

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Andrei L. Gartel

* E-mail: agartel@uic.edu

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

Uppoor G. Bhat,
Marianna Halasi,
Andrei L. Gartel

Published: May 18, 2009
https://doi.org/10.1371/journal.pone.0005592

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Thiazole on normal cells?

Posted by TeckTeh on 19 May 2009 at 14:13 GMT

This is an interesting finding indeed. Just wondering if the authors has tested the Thiazole/Siomycin A on normal primary cells? Do they also show the same potency on inducing apoptosis in normal cells vs cancer cells? If such drugs were to be used to treat cancers, one would expect them to be relatively non-toxic to normal cells.

No competing interests declared.

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Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

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Thiazole on normal cells?

Posted by TeckTeh on 19 May 2009 at 14:13 GMT