The sentence in the second paragraph of the discussion which says “In addition to some reliability concerns depending on the RNA source used to activate RIG-I (49)….” looks misleading as written.
It should read instead: “Upon activation with different viruses, RIG-I conformational changes were observed in every case, while RIG-I oligomerization measured by native PAGE and western blot was variable (49). In addition, a band shift indicates a molecular change and does not necessarily prove oligomerization.”
Reference:
49. Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, et al. (2013) Incoming RNA virus nucleocapsids containing a 59-triphosphorylated genome activate RIG-I and antiviral signaling. Cell host & microbe 13: 336–346.
The authors thank Dr Friedemann Weber for having attracted our attention to this point and they apologize for the inconvenience.
