Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

Wei-Bing Song; Yuan-Yuan Wang; Fan-Su Meng; Qing-Hua Zhang; Jian-Ying Zeng; Li-Ping Xiao; Xin-Pei Yu; Dan-dan Peng; Lei Su; Bing Xiao; Zhen-Shu Zhang

doi:10.1371/journal.pone.0012969

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Open Access

Peer-reviewed

Research Article

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

Wei-Bing Song ,

Contributed equally to this work with: Wei-Bing Song, Yuan-Yuan Wang

* E-mail: songweibing@yahoo.com

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Yuan-Yuan Wang ,

Contributed equally to this work with: Wei-Bing Song, Yuan-Yuan Wang

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Fan-Su Meng,

Affiliation Department of Intensive Care Unit, Traditional Chinese Medical Hospital of ZhongSan City, Zhongshan, China
⨯
Qing-Hua Zhang,

Affiliation Department of Gerontology, 458 Hospital of People's Liberation Army, Guangzhou, China
⨯
Jian-Ying Zeng,

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Li-Ping Xiao,

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Xin-Pei Yu,

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Dan-dan Peng,

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Lei Su,

Affiliation Department of Gerontology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, China
⨯
Bing Xiao,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Zhen-Shu Zhang

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

Wei-Bing Song,
Yuan-Yuan Wang,
Fan-Su Meng,
Qing-Hua Zhang,
Jian-Ying Zeng,
Li-Ping Xiao,
Xin-Pei Yu,
Dan-dan Peng,
Lei Su,
Bing Xiao

Published: September 24, 2010
https://doi.org/10.1371/journal.pone.0012969

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Publisher's Note: Current address update

Posted by PLOS_ONE_Group on 02 Dec 2010 at 23:40 GMT

ntestinal mucosa barrier (IMB) dysfunction results in many notorious diseases for which there are currently few effective treatments.
http://plosone.org/article/info:doi/10.1371/journal.pone.0012969#article1.front1.article-meta1.abstract1.sec1.p1

The first author's current address is Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University

No competing interests declared.

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MAPK signaling cascades
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Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

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Publisher's Note: Current address update

Posted by PLOS_ONE_Group on 02 Dec 2010 at 23:40 GMT