Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes; Natalia Mendes Schöwe; Karla Cristina Monteiro-Silva; Ticiana Baraldi-Tornisielo; Suzzanna Ingryd Gonçalves Souza; Janaina Balthazar; Marilia Silva Albuquerque; Ariadiny Lima Caetano; Tania Araujo Viel; Hudson Sousa Buck

doi:10.1371/journal.pone.0142267

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Research Article

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes ,

Contributed equally to this work with: Marielza Andrade Nunes, Natalia Mendes Schöwe

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Natalia Mendes Schöwe ,

Contributed equally to this work with: Marielza Andrade Nunes, Natalia Mendes Schöwe

Affiliations Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Karla Cristina Monteiro-Silva,

Affiliation Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil
⨯
Ticiana Baraldi-Tornisielo,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Suzzanna Ingryd Gonçalves Souza,

Affiliation Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil
⨯
Janaina Balthazar,

Affiliation Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil
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Marilia Silva Albuquerque,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Ariadiny Lima Caetano,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯
Tania Araujo Viel,

Affiliations Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil, School of Arts, Sciences and Humanities, Universidade de São Paulo, Av. Arlindo Bettio, 1000, São Paulo, SP 03828–080, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Hudson Sousa Buck

* E-mail: hudson.buck@fcmsantacasasp.edu.br

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes,
Natalia Mendes Schöwe,
Karla Cristina Monteiro-Silva,
Ticiana Baraldi-Tornisielo,
Suzzanna Ingryd Gonçalves Souza,
Janaina Balthazar,
Marilia Silva Albuquerque,
Ariadiny Lima Caetano,
Tania Araujo Viel,
Hudson Sousa Buck

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0142267

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Typing errors in the manuscript.

Posted by hudsonbuck on 27 Nov 2015 at 14:51 GMT

I would like to point two typing errors in the manuscript that could lead to doubts in the dose of lithium used in this work.
In the Abstract, 8th line: where is written "(1.2 mg/Kg/day in drinking water)", please change to (0.25 mg/Kg/day in drinking water).
In Results and Discussion, 2nd paragraph, first line: where is written "1.5 mg/day", please change to "0.25 mg/Kg/day".
The dose used (0.25 mg/Kg/day) is correctly described in the last sentence, in the item "2. Treatment" from Materials and Methods Section.
Thank you.
Hudson Buck

No competing interests declared.

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Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

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Typing errors in the manuscript.

Posted by hudsonbuck on 27 Nov 2015 at 14:51 GMT