Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

Laura Pozzi; Iskra Pollak Dorocic; Xinming Wang; Marie Carlén; Konstantinos Meletis

doi:10.1371/journal.pone.0083879

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Research Article

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

Laura Pozzi,

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Iskra Pollak Dorocic,

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Xinming Wang,

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Marie Carlén,

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Konstantinos Meletis

* E-mail: dinos.meletis@ki.se

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

Laura Pozzi,
Iskra Pollak Dorocic,
Xinming Wang,
Marie Carlén,
Konstantinos Meletis

Published: January 16, 2014
https://doi.org/10.1371/journal.pone.0083879

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Posted by kvadovicova on 20 Jan 2017 at 11:39 GMT

Ketamine might directly stimulate vACC.
My circuit-based finding is that vACC directly stimulates serotonergic DRN, whenever we think/interpretete that things are going well for us (and when we reach comfort zone of homeostasis)
I predict that vACC signals well-being.
When we reach biological and social rewards/resources, safety, gain affection, acceptance, care, or achieve our goals or do something well (make someone smile, learn a sport, make a song, build a house, win a job or good prospects)

No competing interests declared.

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Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

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Posted by kvadovicova on 20 Jan 2017 at 11:39 GMT