c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

Ryu Katsumata; Shinsuke Ishigaki; Masahisa Katsuno; Kaori Kawai; Jun Sone; Zhe Huang; Hiroaki Adachi; Fumiaki Tanaka; Fumihiko Urano; Gen Sobue

doi:10.1371/journal.pone.0046185

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Peer-reviewed

Research Article

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

Ryu Katsumata,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Shinsuke Ishigaki,

Affiliations Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan
⨯
Masahisa Katsuno,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Kaori Kawai,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Jun Sone,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Zhe Huang,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Hiroaki Adachi,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Fumiaki Tanaka,

Affiliation Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan
⨯
Fumihiko Urano,

Affiliations Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Gen Sobue

* E-mail: sobueg@med.nagoya-u.ac.jp

Affiliations Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan
⨯

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

Ryu Katsumata,
Shinsuke Ishigaki,
Masahisa Katsuno,
Kaori Kawai,
Jun Sone,
Zhe Huang,
Hiroaki Adachi,
Fumiaki Tanaka,
Fumihiko Urano,
Gen Sobue

Published: September 25, 2012
https://doi.org/10.1371/journal.pone.0046185

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Also a putative EphA4 antagonist

Posted by JJK1 on 02 Oct 2012 at 11:31 GMT

dasatinib
http://plosone.org/article/info:doi/10.1371/journal.pone.0046185#article1.front1.article-meta1.abstract1.sec2.p1

See general comment.

No competing interests declared.

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c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

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Also a putative EphA4 antagonist

Posted by JJK1 on 02 Oct 2012 at 11:31 GMT