Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotoxic Limonoid from Chisocheton erythrocarpus in HSC-4 Human Oral Cancer Cells

Noor Hasima Nagoor; Norliza Shah Jehan Muttiah; Chong Soon Lim; Lionel L. A. In; Khalit Mohammad; Khalijah Awang

doi:10.1371/journal.pone.0023661

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Open Access

Peer-reviewed

Research Article

Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotoxic Limonoid from Chisocheton erythrocarpus in HSC-4 Human Oral Cancer Cells

Noor Hasima Nagoor ,

* E-mail: hasima@um.edu.my (NHN); lionelin@um.edu.my (LLAI)

Affiliation Faculty of Science, Institute of Biological Science (Genetics and Molecular Biology), University Malaya, Kuala Lumpur, Malaysia
⨯
Norliza Shah Jehan Muttiah,

Affiliation Faculty of Science, Institute of Biological Science (Genetics and Molecular Biology), University Malaya, Kuala Lumpur, Malaysia
⨯
Chong Soon Lim,

Affiliation Department of Chemistry, Faculty of Science, Centre for Natural Product Research and Drug Discovery (CENAR), University Malaya, Kuala Lumpur, Malaysia
⨯
Lionel L. A. In ,

* E-mail: hasima@um.edu.my (NHN); lionelin@um.edu.my (LLAI)

Affiliation Faculty of Science, Institute of Biological Science (Genetics and Molecular Biology), University Malaya, Kuala Lumpur, Malaysia
⨯
Khalit Mohammad,

Affiliation Department of Pharmacy, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
⨯
Khalijah Awang

Affiliation Department of Chemistry, Faculty of Science, Centre for Natural Product Research and Drug Discovery (CENAR), University Malaya, Kuala Lumpur, Malaysia
⨯

Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotoxic Limonoid from Chisocheton erythrocarpus in HSC-4 Human Oral Cancer Cells

Noor Hasima Nagoor,
Norliza Shah Jehan Muttiah,
Chong Soon Lim,
Lionel L. A. In,
Khalit Mohammad,
Khalijah Awang

Published: August 17, 2011
https://doi.org/10.1371/journal.pone.0023661

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Author contributions

Posted by lionelin on 07 Sep 2011 at 02:53 GMT

There is a slight change to the author contribution as follows:

Conceived and designed the experiments: NHN NSJM CSL LLAI KM KA.
Performed the experiments: NSJM CSL.
Analyzed the data: NSJM CSL LLAI NHN KA KM.
Contributed reagents/materials/analysis tools: NHN LLAI KM KA.
Wrote the paper: NSJM LLAI CSL NHN KA

No competing interests declared.

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Apoptosis
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DNA fragmentation
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Cancer treatment
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MTT assay
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Cell staining
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Cancers and neoplasms
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Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotoxic Limonoid from Chisocheton erythrocarpus in HSC-4 Human Oral Cancer Cells

Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotoxic Limonoid from Chisocheton erythrocarpus in HSC-4 Human Oral Cancer Cells

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Author contributions

Posted by lionelin on 07 Sep 2011 at 02:53 GMT