Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain

Courtney L. Donica; Yan Cui; Shanping Shi; Howard B. Gutstein

doi:10.1371/journal.pone.0097105

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Open Access

Peer-reviewed

Research Article

Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain

Courtney L. Donica,

Affiliation Department of Anesthesiology, The University of Texas – MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yan Cui,

Affiliation Department of Anesthesiology, The University of Texas – MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Shanping Shi,

Affiliation Department of Anesthesiology, The University of Texas – MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Howard B. Gutstein

* E-mail: hgutstein@mdanderson.org

Affiliations Department of Anesthesiology, The University of Texas – MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas – MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain

Courtney L. Donica,
Yan Cui,
Shanping Shi,
Howard B. Gutstein

Published: May 12, 2014
https://doi.org/10.1371/journal.pone.0097105

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Mistake in Fig1 Legend

Posted by nbeazley-long on 13 Apr 2018 at 15:34 GMT

There appears to be a mistake in the legend for Fig 1B.

(B) Beginning the day after SNL, animals received daily subcutaneous (s.c.) injections of morphine (2.5 mg/kg), imatinib (5 mg/kg), morphine + imatinib or vehicle and mechanical sensitivity determined. "bold italic"Systemic co-administration of morphine and imatinib completely eliminated allodynia after nerve injury. n = 5–9 per group.

Systemic or sub cutaneous? From the methods and results text it is clear that this is s.c. so "systemic" should be removed or replaced with "repeated".

No competing interests declared.

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Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain

Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain

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Mistake in Fig1 Legend

Posted by nbeazley-long on 13 Apr 2018 at 15:34 GMT