Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

Lei Qi; Feng Zhu; Shu-hai Li; Li-bo Si; Li-kuan Hu; Hui Tian

doi:10.1371/journal.pone.0106032

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Open Access

Peer-reviewed

Research Article

Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

Lei Qi,

Affiliation Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China
⨯
Feng Zhu,

Affiliation Department of Thoracic Surgery, Shan dong Provincial Chest Hospital, Jinan, Shandong Province, China
⨯
Shu-hai Li,

Affiliation Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China
⨯
Li-bo Si,

Affiliation Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China
⨯
Li-kuan Hu,

Affiliation Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China
⨯
Hui Tian

* E-mail: tianhuiy@sohu.com

Affiliation Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China
⨯

Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

Lei Qi,
Feng Zhu,
Shu-hai Li,
Li-bo Si,
Li-kuan Hu,
Hui Tian

Published: August 27, 2014
https://doi.org/10.1371/journal.pone.0106032

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siRNA targets?

Posted by afriedl on 10 Aug 2015 at 15:26 GMT

I blasted the siRNA sequences given in the paper for knock-down of Retinoblastoma-binding protein 2 (RBP2= KDM5a), NCBI gene ID 5927. These sequences target Retinol-binding protein 2 (geneID 5948). Does this mean that the wrong gene was knocked-down?

No competing interests declared.

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Non-small cell lung cancer
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Tumor angiogenesis
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Small interfering RNA
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VEGF signaling
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Lung and intrathoracic tumors
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Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

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siRNA targets?

Posted by afriedl on 10 Aug 2015 at 15:26 GMT