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Possible regression to the mean in parts of the trend analysis

Posted by adeckert on 02 Sep 2023 at 17:58 GMT

I am the first author of this publication, and after rereading it after several years because I needed information for another study, I discovered a potential problem that I was not aware of at the time: In the results section, we talk about trends, and there we divided subjects into initial eGFR values below and above 60 ml/min and described their viltration rates after the last measurement. We found that in patients with an initial eGFR above 60 ml/min, the viltration rate deteriorated, whereas in patients with an eGFR below 60 ml/min, it remained the same or ameliorated. However, this could be partly due to the phenomenon called "regression to the mean" and should be considered in the discussion.

No competing interests declared.