Reader Comments
Post a new comment on this article
Post Your Discussion Comment
Please follow our guidelines for comments and review our competing interests policy. Comments that do not conform to our guidelines will be promptly removed and the user account disabled. The following must be avoided:
- Remarks that could be interpreted as allegations of misconduct
- Unsupported assertions or statements
- Inflammatory or insulting language
Thank You!
Thank you for taking the time to flag this posting; we review flagged postings on a regular basis.
closeDissociation between cocaine-primed craving and sensitization
Posted by Ulysse on 31 Dec 2010 at 18:24 GMT
This is an interesting study. It is regrettable, however, that the authors omitted to cite previous research in rats showing the same behavioral dissociation between cocaine-primed craving-like behavior and sensitization (e.g., Ahmed and Cador 2006).
RE: Dissociation between cocaine-primed craving and sensitization
RMBrown replied to Ulysse on 04 Jan 2011 at 05:21 GMT
I agree it is regrettable. In actual fact, the original submission contained significant discussion of this interesting line of research as I thought it highly relevant to the findings of this study. Indeed, the specific article you mention was cited, along with others (e.g. Lenoir and Ahmed 2007; Ahmed et al., 2002; Vanderschuren and Everitt, 2004). During the revision process the article was heavily truncated and the final version did not include this section of the discussion (regrettably). The findings from Ahmed and Cador (2006) and Lenoir and Ahmed (2007) suggest that responding to drug priming is specific to compulsive drug use and dissociable from drug reward and sensitization. The findings of the present study provide new evidence to support this hypothesis, using a different model of reinstatement – the CPP paradigm.