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Another Excellent study linking RMP to Cell Volume

Posted by RichardBJ on 19 Oct 2017 at 14:59 GMT

I was delighted to read this fascinating article. Cell volume regulation is fundamental to all cells and I am so surprised so few papers have picked up on the relationship between RMP and RVD previously.
Just a minor correction to the citation of our work which showed similar previously. we are listed as reference [18] but with no page or volume number.
The full citation [reference 18] should be: Lewis R, Asplin KE, Bruce G, Dart C, Mobasheri A, Barrett-Jolley R. The role of the membrane potential in chondrocyte volume regulation. J Cell Physiol 2011; 226: 2979-2986.
Thanks. I am hopeful that people will read the current report, and our own and start to test the hypothesis in further cell types.
I wondered if the authors had considered sharp electrode potential measurement of RMP too though. The dye method here has clearly tested the hypothesis, but usually the calibration of dyes requires that one know the membrane potential to be largely dependent on potassium ions? Is that the case with this dye?
The inclusion of the model in this paper is a strong point. In our own paper (reference 18]) our original version had a much fuller mathematical model indluced, but the Editor/reviewers asked us to remove it as it was seen as unecessary (not wrong!).
I hope to see more of this, numerical and quantitative linking of RMP and cell volume!
Good Work!!
Richard

Competing interests declared: Only that I also publish in this area.
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