Reviewer 2's Review
“This seems an interesting analysis of the applicability of proteonomic analysis to diagnosis of VTE.
The issues of such new parameters include:
- reproducibility of all lab methods
- practical application. Are all centres likely to have the technology to perform such analyses? I suspect not. Perhaps show a proposed diagnostic algorithm to illustrate how this technology would fit into current VTE diagnosis, based on clinical pre-test probability.
- smallish numbers of the validation cohort.
Table 1 needs much more information eg. comorbidities, concomitant therapies, renal function, LV function, etc.”
N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.
