Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death

Mohammad Waseem; Upasana Sahu; Mohd. Salman; Arnab Choudhury; Sudeshna Kar; Heena Tabassum; Suhel Parvez

doi:10.1371/journal.pone.0180953

Loading metrics

Open Access

Peer-reviewed

Research Article

Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death

Mohammad Waseem ,

Contributed equally to this work with: Mohammad Waseem, Upasana Sahu, Mohd. Salman

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Upasana Sahu ,

Contributed equally to this work with: Mohammad Waseem, Upasana Sahu, Mohd. Salman

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India, Jamia Hamdard-Institute of Molecular Medicine, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Mohd. Salman ,

Contributed equally to this work with: Mohammad Waseem, Upasana Sahu, Mohd. Salman

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Arnab Choudhury,

Roles Methodology

Affiliation Jamia Hamdard-Institute of Molecular Medicine, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Sudeshna Kar,

Roles Formal analysis, Validation

Affiliation Jamia Hamdard-Institute of Molecular Medicine, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Heena Tabassum,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry, Jamia Hamdard (Hamdard University), New Delhi, India
⨯
Suhel Parvez

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: drsuhelparvez@yahoo.com, sparvez@jamiahamdard.ac.in

Affiliation Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India
⨯

Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death

Mohammad Waseem,
Upasana Sahu,
Mohd. Salman,
Arnab Choudhury,
Sudeshna Kar,
Heena Tabassum,
Suhel Parvez

Published: July 21, 2017
https://doi.org/10.1371/journal.pone.0180953

Reader Comments

Post a new comment on this article

Why Melatonin?

Posted by zhashmi on 23 Feb 2019 at 11:00 GMT

Melatonin regulates circadian rhythm and can act as sedative.
Knowing this mechanism of action why specifically melatonin was chosen for the treatment in this paper. Any other antioxidant could have serve the same purpose.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Computer software
Is the Subject Area "Computer software" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.
Cell membranes
Is the Subject Area "Cell membranes" applicable to this article?

Thanks for your feedback.
Superoxides
Is the Subject Area "Superoxides" applicable to this article?

Thanks for your feedback.

Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death

Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Why Melatonin?

Posted by zhashmi on 23 Feb 2019 at 11:00 GMT