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Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 12 Jun 2007 at 13:54 GMT

Reviewer 1's Review

“This is clearly one of the best papers I received for reviewing in the last couple of years. The experiments are very well designed, the results are convincing and presented in a very nice set of figures, and the manuscript is written concisely and straight to the point.

The strength of this paper is the combination of a pharmacological approach with gene expression and RNAi analyses, which, together, make a strong point for the involvement of the TOR pathway in the caste-specific development of honey bee queen and worker larvae.”

N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.