Genetic Evidence for a Link Between Glycolysis and DNA Replication

Laurent Jannière; Danielle Canceill; Catherine Suski; Sophie Kanga; Bérengère Dalmais; Roxane Lestini; Anne-Françoise Monnier; Jérôme Chapuis; Alexander Bolotin; Marina Titok; Emmanuelle Le Chatelier; S. Dusko Ehrlich

doi:10.1371/journal.pone.0000447

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Open Access

Peer-reviewed

Research Article

Genetic Evidence for a Link Between Glycolysis and DNA Replication

Laurent Jannière ,

*To whom correspondence should be addressed. E-mail: laurent.janniere@jouy.inra.fr

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Danielle Canceill,

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Catherine Suski,

Current address: Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Sophie Kanga,

Current address: Laboratoire Régulation de l'Expression Génique chez les Microorganismes, CNRS-UPR9073, Institut de Biologie Physico-Chimique, Paris, France

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Bérengère Dalmais,

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Roxane Lestini,

Current address: Centre de Génétique Moléculaire CNRS Bâtiment 26, Gif-sur-Yvette, France

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Anne-Françoise Monnier,

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Jérôme Chapuis,

Current address: Laboratoire de Virologie Immunologie Moléculaire, INRA, Jouy en Josas, France

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Alexander Bolotin,

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Marina Titok,

Current address: Belarussian State University, Biological Faculty, Department of Genetics and Biotechnology, Minsk, Belarus

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
Emmanuelle Le Chatelier,

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯
S. Dusko Ehrlich

Affiliation Laboratoire de Génétique Microbienne, INRA, Jouy en Josas, France
⨯

Genetic Evidence for a Link Between Glycolysis and DNA Replication

Laurent Jannière,
Danielle Canceill,
Catherine Suski,
Sophie Kanga,
Bérengère Dalmais,
Roxane Lestini,
Anne-Françoise Monnier,
Jérôme Chapuis,
Alexander Bolotin,
Marina Titok

Published: May 16, 2007
https://doi.org/10.1371/journal.pone.0000447

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Related findings in yeast

Posted by kupiec on 10 Jun 2007 at 12:29 GMT

It is proposed that related systems are ubiquitous.
http://plosone.org/article/info:doi/10.1371/journal.pone.0000447#article1.front1.article-meta1.abstract1.sec3.p1

In the budding yeast Saccharomyces cerevisiae the Cdc40 gene encodes a splicing factor with a role in cell cycle progression (DNA replication). cdc40 mutants are sensitive to the replication inhibitor Hydroxyurea. A screen for high-copy number suppressors of the sensitivity uncovered many genes involved in glycolysis/gluconeogenesis:

Kaplan Y, Kupiec M.
A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.
Curr Genet. 2007 Feb;51(2):123-40. Epub 2006 Dec 14.
PMID: 17171376

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Genetic Evidence for a Link Between Glycolysis and DNA Replication

Genetic Evidence for a Link Between Glycolysis and DNA Replication

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Related findings in yeast

Posted by kupiec on 10 Jun 2007 at 12:29 GMT