A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova; Greggory S. LaBerge; Eric Duvall; Nicole Spoelstra; Vincent Klump; Mario Sznol; Dennis Cooper; Richard A. Spritz; Joseph T. Chang; John M. Pawelek

doi:10.1371/journal.pone.0066731

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Open Access

Peer-reviewed

Research Article

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova ,

Contributed equally to this work with: Rossitza Lazova, Greggory S. LaBerge

Affiliations Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America, The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America
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Greggory S. LaBerge ,

Contributed equally to this work with: Rossitza Lazova, Greggory S. LaBerge

Affiliations Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America, Denver Police Department Crime Lab, Denver, Colorado, United States of America
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Eric Duvall,

Affiliation Denver Police Department Crime Lab, Denver, Colorado, United States of America
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Nicole Spoelstra,

Affiliation Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
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Vincent Klump,

Affiliation Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Mario Sznol,

Affiliations The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America, Medical Oncology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Dennis Cooper,

Affiliations The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America, Medical Oncology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Richard A. Spritz,

Affiliation Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America
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Joseph T. Chang,

Affiliation Statistics Department, Yale University, New Haven, Connecticut, United States of America
⨯
John M. Pawelek

* E-mail: john.pawelek@yale.edu

Affiliations Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America, The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America
⨯

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova,
Greggory S. LaBerge,
Eric Duvall,
Nicole Spoelstra,
Vincent Klump,
Mario Sznol,
Dennis Cooper,
Richard A. Spritz,
Joseph T. Chang,
John M. Pawelek

Published: June 26, 2013
https://doi.org/10.1371/journal.pone.0066731

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Patient's Lymphoma

Posted by jpawelek on 06 Jul 2013 at 13:25 GMT

The patient had diffuse large B cell lymphoma. He never had relapse after transplant. The patient was in remission when transplanted and presumably next to none the patient’s cells were lymphoma cells.

John Pawelek, Corresponding Author

No competing interests declared.

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A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

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Patient's Lymphoma

Posted by jpawelek on 06 Jul 2013 at 13:25 GMT