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closeCorrection for Hase et al., Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease (PLoS ONE 3: e3033, 2008)
Posted by hohno on 14 Feb 2011 at 06:27 GMT
We report here that AID−/− mice spontaneously develop tertiary lymphoid organs (TLOs)
http://plosone.org/article/info:doi/10.1371/journal.pone.0003033#article1.front1.article-meta1.abstract1.p1
The authors note the following: Regarding the genotype of the AID-deficient mice reported in this paper, it turned out that these mice carry another mutation in addition to AID gene deletion, which had not been aware of, when we obtained the mice. Detailed analyses performed by Dr. Taku Okazaki of the University of Tokushima revealed that the phenotype of autoimmune gastritis is due to the combination of AID-deficiency and the second mutation called aida, but not due to the AID single deletion (Okazaki et al., “PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice” J. Exp. Med; doi: 10.1084/jem.20100466). We confirmed by genomic DNA sequencing of our AID-deficient mice colony that these mice possess the aida mutation in addition to AID-deficiency. Therefore, we conclude that the autoimmune gastritis observed in this study is due to the combination of AID-deficiency and the aida mutation.