Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

Carole L. Galligan; Janet C. Siebert; Katherine A. Siminovitch; Edward C. Keystone; Vivian Bykerk; Omar D. Perez; Eleanor N. Fish

doi:10.1371/journal.pone.0006703

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Open Access

Peer-reviewed

Research Article

Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

Carole L. Galligan,

Affiliation Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
⨯
Janet C. Siebert,

Affiliation CytoAnalytics, Analytical Services, Denver, Colorado, United States of America
⨯
Katherine A. Siminovitch,

Affiliation Mount Sinai Hospital Samuel Lunenfeld and Toronto Hospital Research Institutes, Toronto, Ontario, Canada
⨯
Edward C. Keystone,

Affiliation University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada
⨯
Vivian Bykerk,

Affiliation University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada
⨯
Omar D. Perez,

Current address: Tocagen, Director of Preclinical Development, San Diego, California, United States of America

Affiliation The Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Eleanor N. Fish

* E-mail: en.fish@utoronto.ca

Affiliation Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
⨯

Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

Carole L. Galligan,
Janet C. Siebert,
Katherine A. Siminovitch,
Edward C. Keystone,
Vivian Bykerk,
Omar D. Perez,
Eleanor N. Fish

Published: August 20, 2009
https://doi.org/10.1371/journal.pone.0006703

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clarification

Posted by cgalligan on 17 Sep 2009 at 21:30 GMT

and was identified in 4 or more of the respective ERA or OA patient cohorts. This screen identified specific signaling effectors that were credible classifiers - those in which populations were reasonably well separated (>10% above control max. MFI value) and were identified in 4 or more of the respective ERA or OA patient cohorts

No competing interests declared.

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Lymphocytes
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Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

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clarification

Posted by cgalligan on 17 Sep 2009 at 21:30 GMT