Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Miles Trupp; Hongjie Zhu; William R. Wikoff; Rebecca A. Baillie; Zhao-Bang Zeng; Peter D. Karp; Oliver Fiehn; Ronald M. Krauss; Rima Kaddurah-Daouk

doi:10.1371/journal.pone.0038386

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Peer-reviewed

Research Article

Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Miles Trupp ,

Contributed equally to this work with: Miles Trupp, Hongjie Zhu

Current address: Umeå University, Department of Pharmacology and Clinical Neuroscience, Umeå, Sweden

Affiliation Bioinformatics Research Group, AI Center, SRI International, Menlo Park, California, United States of America
⨯
Hongjie Zhu ,

Contributed equally to this work with: Miles Trupp, Hongjie Zhu

Affiliation Duke University Medical Center, Durham, North Carolina, United States of America
⨯
William R. Wikoff ,

¶These authors also contributed equally to this work

Affiliation Genomics Center, University of California, Davis, California, United States of America
⨯
Rebecca A. Baillie ,

¶These authors also contributed equally to this work

Affiliation Rosa and Company, Cupertino, California, United States of America
⨯
Zhao-Bang Zeng,

Affiliation Bioinformatics Research Center, NC State University, Raleigh, North Carolina, United States of America
⨯
Peter D. Karp,

Affiliation Bioinformatics Research Group, AI Center, SRI International, Menlo Park, California, United States of America
⨯
Oliver Fiehn,

Affiliation Genomics Center, University of California, Davis, California, United States of America
⨯
Ronald M. Krauss ,

* E-mail: kaddu001@mc.duke.edu (RK-D); rkrauss@chori.org (RMK)

Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Rima Kaddurah-Daouk

* E-mail: kaddu001@mc.duke.edu (RK-D); rkrauss@chori.org (RMK)

Affiliation Duke University Medical Center, Durham, North Carolina, United States of America
⨯

Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Miles Trupp,
Hongjie Zhu,
William R. Wikoff,
Rebecca A. Baillie,
Zhao-Bang Zeng,
Peter D. Karp,
Oliver Fiehn,
Ronald M. Krauss,
Rima Kaddurah-Daouk

Published: July 9, 2012
https://doi.org/10.1371/journal.pone.0038386

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Publisher's Note: Error in Figure 1 Legend

Posted by PLOS_ONE_Group on 15 Apr 2013 at 16:23 GMT

There was an error in the Figure 1 legend. The correct version of the legend is:

Figure 1. Correlation matrix of metabolites altered by simvastatin in full range participants. Correlations among metabolites in Table 1 were obtained by deriving a Spearman’s correlation coefficient between each pair of metabolites. The color scheme corresponds to correlation
strength as shown by the color bar. Abbreviations: NIST, National Institute of Standards and Technology.
doi:10.1371/journal.pone.0038386.g001

No competing interests declared.

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Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

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Publisher's Note: Error in Figure 1 Legend

Posted by PLOS_ONE_Group on 15 Apr 2013 at 16:23 GMT