Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

Andrea Procaccini; Bryan Lunt; Hendrik Szurmant; Terence Hwa; Martin Weigt

doi:10.1371/journal.pone.0019729

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Research Article

Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

Andrea Procaccini,

Affiliations Human Genetics Foundation, Torino, Italy, Center for Computational Studies and Dipartimento di Fisica, Politecnico di Torino, Torino, Italy
⨯
Bryan Lunt,

Affiliation Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America
⨯
Hendrik Szurmant ,

* E-mail: szurmant@scripps.edu (HS); hwa@ucsd.edu (TW); martin.weigt@hugef-torino.org (MW)

Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Terence Hwa ,

* E-mail: szurmant@scripps.edu (HS); hwa@ucsd.edu (TW); martin.weigt@hugef-torino.org (MW)

Affiliation Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America
⨯
Martin Weigt

* E-mail: szurmant@scripps.edu (HS); hwa@ucsd.edu (TW); martin.weigt@hugef-torino.org (MW)

Affiliations Human Genetics Foundation, Torino, Italy, Center for Computational Studies and Dipartimento di Fisica, Politecnico di Torino, Torino, Italy
⨯

Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

Andrea Procaccini,
Bryan Lunt,
Hendrik Szurmant,
Terence Hwa,
Martin Weigt

Published: May 9, 2011
https://doi.org/10.1371/journal.pone.0019729

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Correction

Posted by weigt on 31 May 2011 at 09:27 GMT

We recently learned that DivK is indeed an efficient in-vitro phosphotransfer partner for CC_0568 (Michael Laub, personal communication), suggesting that all these predictions might be correct.
http://plosone.org/article/info:doi/10.1371/journal.pone.0019729#article1.body1.sec2.sec4.p3

The communication by Michael Laub actually concerned phosphotransfer between DivK and CC_1062 (CckN), and not for DivK/CC_0586. This result confirms earlier yeast-two-hybrid results [24] mentioned above, cf. also Fig.4. Therefore it does not provide another test for our prediction.

No competing interests declared.

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Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

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Correction

Posted by weigt on 31 May 2011 at 09:27 GMT