Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

Jeremy D. K. Parker; Brian A. Bradley; Arne O. Mooers; Lynne M. Quarmby

doi:10.1371/journal.pone.0001076

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Research Article

Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

Jeremy D. K. Parker ,

Contributed equally to this work with: Jeremy D. K. Parker, Brian A. Bradley

Affiliation Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
⨯
Brian A. Bradley ,

Contributed equally to this work with: Jeremy D. K. Parker, Brian A. Bradley

Affiliation Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
⨯
Arne O. Mooers,

Affiliation Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
⨯
Lynne M. Quarmby

*To whom correspondence should be addressed. E-mail: quarmby@sfu.ca

Affiliation Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
⨯

Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

Jeremy D. K. Parker,
Brian A. Bradley,
Arne O. Mooers,
Lynne M. Quarmby

Published: October 24, 2007
https://doi.org/10.1371/journal.pone.0001076

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Unfortunate absence of NEK10

Posted by Gerard_Manning on 06 Nov 2007 at 17:45 GMT

exclude the predicted human Nek10
http://plosone.org/article/info:doi/10.1371/journal.pone.0001076#article1.body1.sec2.p1

The omission of NEK10 is unfortunate, as full length sequences with kinase domains do exist. We have found highly likely NEK10 homologs in organisms as diverse as C. elegans and Nematostella, and it may be that careful analysis would show and even deeper history. Contrary to a later statement, NEK10 has a non-kinase but conserved N-terminal domain, in contrast to other metazoan NEKs.

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Phylogenetic analysis
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Cell cycle and cell division
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Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

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Unfortunate absence of NEK10

Posted by Gerard_Manning on 06 Nov 2007 at 17:45 GMT