Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

Christian Roussilhon; Philippe Brasseur; Patrice Agnamey; Jean-Louis Pérignon; Pierre Druilhe

doi:10.1371/journal.pone.0009309

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Open Access

Peer-reviewed

Research Article

Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

Christian Roussilhon,

Affiliation Unité de Parasitologie Bio-Médicale, Institut Pasteur, Paris, France
⨯
Philippe Brasseur,

Affiliation UMR 198, Institut de Recherche pour le Développement, Dakar, Sénégal
⨯
Patrice Agnamey,

Affiliation Laboratoire de Parasitologie-Mycologie, Hopital Sud, CHU d'Amiens, Amiens, France
⨯
Jean-Louis Pérignon,

Affiliation Unité de Parasitologie Bio-Médicale, Institut Pasteur, Paris, France
⨯
Pierre Druilhe

* E-mail: druilhe@pasteur.fr

Affiliation Unité de Parasitologie Bio-Médicale, Institut Pasteur, Paris, France
⨯

Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

Christian Roussilhon,
Philippe Brasseur,
Patrice Agnamey,
Jean-Louis Pérignon,
Pierre Druilhe

Published: February 19, 2010
https://doi.org/10.1371/journal.pone.0009309

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promisses the solution but comes short

Posted by mnacher on 29 Aug 2010 at 23:50 GMT

The narrative seems selective (worms are bad for malaria. period) and does not give a balanced view of the litterature on human malaria.
The analysis stopped short of testing their main hypothesis. It is surprising since the answer to the hypothesis seems to be in the data. Worms, malaria incidence, and IGG responses could be in the same multivariate model. It seems like a missed opportunity to give a good test to their hypothesis.

No competing interests declared.

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Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

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promisses the solution but comes short

Posted by mnacher on 29 Aug 2010 at 23:50 GMT