Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)

Louisa G. Sylvia; Andrew M. Busch; Dustin J. Rabideau; Alexandra Gold; Suzanne C. Danhauer; Heather T. Schatten; Douglas Katz; Lauren M. Weinstock; Jennifer Dahne; Sabine P. Schmid; Zainab Soetan; Roberta Tovey; Kedie Pintro; Adrienne Kvaka; Antonietta Alvarez Hernandez; Ingrid Hsu; Alba Melendez; Melissa Adkins-Hempel; Angela Grubb; Odalys Lozado; Atefeh Alavi Fili; Giuliana Chau; Lisa A. Uebelacker

doi:10.1371/journal.pone.0315506

Loading metrics

Open Access

Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)

Louisa G. Sylvia ,

Contributed equally to this work with: Louisa G. Sylvia, Andrew M. Busch

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft

* E-mail: lsylvia2@mgh.harvard.edu

Affiliations Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Andrew M. Busch ,

Contributed equally to this work with: Louisa G. Sylvia, Andrew M. Busch

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft

Affiliations Hennepin Healthcare, Minneapolis, Minnesota, United States of America, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
⨯
Dustin J. Rabideau,

Roles Data curation, Formal analysis, Software, Validation

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Alexandra Gold,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Suzanne C. Danhauer,

Roles Project administration, Writing – review & editing

Affiliation Atrium Health Wake Forest Baptist, Wake Forest, North Carolina, United States of America
⨯
Heather T. Schatten,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Douglas Katz,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Lauren M. Weinstock,

Roles Project administration, Writing – review & editing

Affiliation Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯
Jennifer Dahne,

Roles Project administration, Writing – review & editing

Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Sabine P. Schmid,

Roles Project administration, Writing – review & editing

Affiliation University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
⨯
Zainab Soetan,

Roles Data curation, Formal analysis, Software, Validation

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Roberta Tovey,

Roles Visualization

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Kedie Pintro,

Roles Data curation, Formal analysis, Software, Validation

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Adrienne Kvaka,

Roles Project administration, Writing – review & editing

Affiliation Butler Hospital, Providence, Rhode Island, United States of America
⨯
Antonietta Alvarez Hernandez,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Ingrid Hsu,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Alba Melendez,

Roles Project administration, Writing – review & editing

Affiliation Atrium Health Wake Forest Baptist, Wake Forest, North Carolina, United States of America
⨯
Melissa Adkins-Hempel,

Roles Project administration, Writing – review & editing

Affiliation Hennepin Healthcare, Minneapolis, Minnesota, United States of America

https://orcid.org/0000-0002-9157-4469

⨯
Angela Grubb,

Roles Project administration, Writing – review & editing

Affiliation Atrium Health Wake Forest Baptist, Wake Forest, North Carolina, United States of America
⨯
Odalys Lozado,

Roles Project administration, Writing – review & editing

Affiliation Hennepin Healthcare, Minneapolis, Minnesota, United States of America
⨯
Atefeh Alavi Fili,

Roles Project administration, Writing – review & editing

Affiliation Hennepin Healthcare, Minneapolis, Minnesota, United States of America
⨯
Giuliana Chau,

Roles Project administration, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
[ ... ],
Lisa A. Uebelacker

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft

Affiliations Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, Butler Hospital, Providence, Rhode Island, United States of America
⨯
[ view all ]
[ view less ]

Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)

Louisa G. Sylvia,
Andrew M. Busch,
Dustin J. Rabideau,
Alexandra Gold,
Suzanne C. Danhauer,
Heather T. Schatten,
Douglas Katz,
Lauren M. Weinstock,
Jennifer Dahne,
Sabine P. Schmid

Published: January 6, 2025
https://doi.org/10.1371/journal.pone.0315506

Reader Comments

Post a new comment on this article

Typographical Correction

Posted by PLOS_ONE_Group on 04 May 2026 at 18:21 GMT

The authors would like to clarify the following: In the Statistical analysis subsection of the Study design, there is an error in the first sentence of the second paragraph. The correct sentence is: Assuming an actual mean difference of zero, a standard deviation of 7 in both arms, and a 25% dropout rate by week 24, a sample size of 518 (259 participants per arm) provides 80% power to establish the noninferiority of the YI versus BA based on a one-sided 2.5% significance level t-test against the margin of -2 points.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Depression
Is the Subject Area "Depression" applicable to this article?

Thanks for your feedback.
Mental health therapies
Is the Subject Area "Mental health therapies" applicable to this article?

Thanks for your feedback.
Psychotherapy
Is the Subject Area "Psychotherapy" applicable to this article?

Thanks for your feedback.
Behavior
Is the Subject Area "Behavior" applicable to this article?

Thanks for your feedback.
Social media
Is the Subject Area "Social media" applicable to this article?

Thanks for your feedback.
Suicide
Is the Subject Area "Suicide" applicable to this article?

Thanks for your feedback.
Antidepressant drug therapy
Is the Subject Area "Antidepressant drug therapy" applicable to this article?

Thanks for your feedback.
Treatment guidelines
Is the Subject Area "Treatment guidelines" applicable to this article?

Thanks for your feedback.

Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)

Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Typographical Correction

Posted by PLOS_ONE_Group on 04 May 2026 at 18:21 GMT