A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee; Maruja E. Lira; Adam Pavlicek; Jingjing Ye; Dana Buckman; Shubha Bagrodia; Sreesha P. Srinivasa; Yongjun Zhao; Samuel Aparicio; Paul A. Rejto; James G. Christensen; Keith A. Ching

doi:10.1371/journal.pone.0039653

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Open Access

Peer-reviewed

Research Article

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Maruja E. Lira,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Adam Pavlicek,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Jingjing Ye,

Current address: Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America

Affiliation Global Pre-Clinical Statistics, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Dana Buckman,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Shubha Bagrodia,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Sreesha P. Srinivasa,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Yongjun Zhao,

Affiliation Michael Smith Genome Sciences Centre, BC Cancer Research Centre, Vancouver, British Columbia, Canada
⨯
Samuel Aparicio,

Affiliations Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada, Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Paul A. Rejto,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
James G. Christensen,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Keith A. Ching

* E-mail: keith.ching@pfizer.com

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee,
Maruja E. Lira,
Adam Pavlicek,
Jingjing Ye,
Dana Buckman,
Shubha Bagrodia,
Sreesha P. Srinivasa,
Yongjun Zhao,
Samuel Aparicio,
Paul A. Rejto

Published: June 22, 2012
https://doi.org/10.1371/journal.pone.0039653

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TCGA Reference

Posted by killerz on 21 Sep 2013 at 01:14 GMT

The results published here are in whole or part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at http://cancergenome.nih.g... Study Accession: phs000178.v2.p2

No competing interests declared.

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A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

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TCGA Reference

Posted by killerz on 21 Sep 2013 at 01:14 GMT