Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

Jorieke H. Peters; Luuk B. Hilbrands; Hans J. P. M. Koenen; Irma Joosten

doi:10.1371/journal.pone.0002233

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Peer-reviewed

Research Article

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4^posCD25^high T Cells for Immunotherapy

Jorieke H. Peters,

Affiliation Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Luuk B. Hilbrands,

Affiliation Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Hans J. P. M. Koenen,

Affiliation Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Irma Joosten

* E-mail: I.Joosten@abti.umcn.nl

Affiliation Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4^posCD25^high T Cells for Immunotherapy

Jorieke H. Peters,
Luuk B. Hilbrands,
Hans J. P. M. Koenen,
Irma Joosten

Published: May 21, 2008
https://doi.org/10.1371/journal.pone.0002233

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Posted by NiyazAhmed on 29 Jun 2008 at 05:23 GMT

Selected by: Mohamed Sayegh with Jessamyn Bagley, Brigham and Women’s Hospital and Children’s Hospital Boston, United States of America [IMMUNOLOGY]
Evaluated 19 Jun 2008

Tags: Tech Advance
F1000 Factor: 3.0

Comments:
The authors describe an efficient protocol for the generation of antigen-specific human regulatory T cells (Treg). This may advance the goal of using Treg to generate specific tolerance to antigens, such as those present on organ allografts.

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Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4^posCD25^high T Cells for Immunotherapy

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4^posCD25^high T Cells for Immunotherapy

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Posted by NiyazAhmed on 29 Jun 2008 at 05:23 GMT