A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates

Chen Chen; Jiaqi Tang; Wei Dong; Changjun Wang; Youjun Feng; Jing Wang; Feng Zheng; Xiuzhen Pan; Di Liu; Ming Li; Yajun Song; Xinxing Zhu; Haibo Sun; Tao Feng; Zhaobiao Guo; Aiping Ju; Junchao Ge; Yaqing Dong; Wen Sun; Yongqiang Jiang; Jun Wang; Jinghua Yan; Huanming Yang; Xiaoning Wang; George F. Gao; Ruifu Yang; Jian Wang; Jun Yu

doi:10.1371/journal.pone.0000315

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Peer-reviewed

Research Article

A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates

Chen Chen ,

Contributed equally to this work with: Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Jiaqi Tang ,

Contributed equally to this work with: Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Wei Dong ,

Contributed equally to this work with: Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Changjun Wang ,

Contributed equally to this work with: Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Youjun Feng ,

Contributed equally to this work with: Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng

Affiliations Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China, China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate University, Chinese Academy of Sciences, Beijing, China
⨯
Jing Wang,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Feng Zheng,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Xiuzhen Pan,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Di Liu,

Affiliations Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China, China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Ming Li,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Yajun Song,

Affiliation Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
⨯
Xinxing Zhu,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Haibo Sun,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Tao Feng,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Zhaobiao Guo,

Affiliation Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
⨯
Aiping Ju,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Junchao Ge,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Yaqing Dong,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Wen Sun,

Affiliation Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
⨯
Yongqiang Jiang,

Affiliation Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
⨯
Jun Wang,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China, The Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
⨯
Jinghua Yan,

Affiliations Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China, China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Huanming Yang,

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
Xiaoning Wang ,

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliation School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China
⨯
George F. Gao ,

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliations Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China, China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Ruifu Yang ,

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliation Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
⨯
Jian Wang ,

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
[ ... ],
Jun Yu

*To whom correspondence should be addressed. E-mail: tjq85@hotmail.com (JT); xnwang@21cn.net (XW); gaof@im.ac.cn (GG); yangrf@nic.bmi.ac.cn (RY); wangjian@genomics.org.cn (JW); junyu@genomics.org.cn (JY)

Affiliations Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou, China
⨯
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A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates

Chen Chen,
Jiaqi Tang,
Wei Dong,
Changjun Wang,
Youjun Feng,
Jing Wang,
Feng Zheng,
Xiuzhen Pan,
Di Liu,
Ming Li

Published: March 21, 2007
https://doi.org/10.1371/journal.pone.0000315

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STSS w/out superantigens?

Posted by Paul_Orwin on 28 Mar 2007 at 03:37 GMT

The staphylococcal TSS pathogenesis is very well established to be based on the activity of SAg. Likewise, STSS and Necrotizing Fasciitis caused by GAS are very strongly associated with Spe (pyrogenic exotoxins). It is odd in the extreme to associate this organism with STSS without any SPE association. The shock response is hard to square with this. I tend to think that there needs to be proposed non-SAg pathogenesis pathway to support this contention. Alternatively, there might be a novel mitogen present that hasn't previously been identified. Given the extraordinary number of SAg identified in Staph and Strep, it's easier to imagine that the toxin in question was not found, rather than that it doesn't exist.

RE: STSS w/out superantigens?

TJQ85 replied to Paul_Orwin on 09 Apr 2007 at 07:19 GMT

Sir, I do appreciate your comments. Presently, I also tend to suspect that there might be a novel mitogen present that hasn't previously been identified.

We are trying to pursue it now!

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A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates

A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates

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STSS w/out superantigens?

Posted by Paul_Orwin on 28 Mar 2007 at 03:37 GMT

RE: STSS w/out superantigens?

TJQ85 replied to Paul_Orwin on 09 Apr 2007 at 07:19 GMT