The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Rui Chen; Min Xu; Jason S. Nagati; Richard T. Hogg; Alok Das; Robert D. Gerard; Joseph A. Garcia

doi:10.1371/journal.pone.0116515

Loading metrics

Open Access

Peer-reviewed

Research Article

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Rui Chen ,

* E-mail: joseph.garcia@utsouthwestern.edu (JG); 101011816@seu.edu.cn (RC)

Affiliations Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China
⨯
Min Xu,

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Jason S. Nagati,

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Richard T. Hogg,

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Alok Das,

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Robert D. Gerard,

Affiliation Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Joseph A. Garcia

* E-mail: joseph.garcia@utsouthwestern.edu (JG); 101011816@seu.edu.cn (RC)

Affiliations Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, Texas, United States of America
⨯

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Rui Chen,
Min Xu,
Jason S. Nagati,
Richard T. Hogg,
Alok Das,
Robert D. Gerard,
Joseph A. Garcia

Published: February 17, 2015
https://doi.org/10.1371/journal.pone.0116515

Reader Comments

Post a new comment on this article

Correction for Figure 8

Posted by JosephGarcia on 19 Feb 2015 at 18:19 GMT

There was a formatting error in the current version of Figure 8 that resulted in displaced text. We anticipate that a corrected version will be available soon. JG

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
HT1080 cells
Is the Subject Area "HT1080 cells" applicable to this article?

Thanks for your feedback.
Glucose signaling
Is the Subject Area "Glucose signaling" applicable to this article?

Thanks for your feedback.
Acetylation
Is the Subject Area "Acetylation" applicable to this article?

Thanks for your feedback.
Stress signaling cascade
Is the Subject Area "Stress signaling cascade" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Correction for Figure 8

Posted by JosephGarcia on 19 Feb 2015 at 18:19 GMT