High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

Ehud Goldin; Wei Zheng; Omid Motabar; Noel Southall; Jae Hyuk Choi; Juan Marugan; Christopher P. Austin; Ellen Sidransky

doi:10.1371/journal.pone.0029861

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Open Access

Peer-reviewed

Research Article

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

Ehud Goldin ,

* E-mail: goldine@mail.nih.gov

Affiliation Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Wei Zheng,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Omid Motabar,

Affiliations Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Noel Southall,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jae Hyuk Choi,

Affiliations Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juan Marugan,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Christopher P. Austin,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ellen Sidransky

Affiliation Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

Ehud Goldin,
Wei Zheng,
Omid Motabar,
Noel Southall,
Jae Hyuk Choi,
Juan Marugan,
Christopher P. Austin,
Ellen Sidransky

Published: January 17, 2012
https://doi.org/10.1371/journal.pone.0029861

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Misrepresented legends & confusion between compound ID

Posted by julcruanes on 22 Jun 2013 at 14:13 GMT

I noticed that legends for Figures 6 and 8 have been inter-switched.
I also noticed that Table 2 describes NCGC00182186 as an activator and NCGC00182510 as an inhibitor; however, in Figure 8 (Histogram Translocation Assay) the results demonstrate reverse function. Moreover, the legend mentions "activator NCGC00182510".

No competing interests declared.

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High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

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Misrepresented legends & confusion between compound ID

Posted by julcruanes on 22 Jun 2013 at 14:13 GMT