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closeSupports my hypothesis
Posted by patplos123 on 27 Aug 2015 at 01:12 GMT
In 1982 I hypothesised that the inconsistent relationship between above average adiposity in humans and metabolic abnormalities particularly between various population groups could be explained by transgenerational “genetic or hereditary”( i.e. epigenetic) changes. I also suggested that this process reflected an adaptive response to the modern obesogenic nutritional environment [1].
I also believe that I was the first to suggest an inverse relationship between weight in infancy due to epigenetic influences and the risk of subsequent metabolic disorders.
This study by Alice Tait and colleagues demonstrating that second and third generation rat offspring exposed to an obesogenic nutritional environment displayed reduced body fat to lean mass and reduced appetite suggesting a reduction in chronic disease risk across generations is consistent with this hypothesis.
1.
Bradley PJ. Is obesity an advantageous adaptation ? Int J Obesity 1982; 6:43-52.