Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

John Gatfield; Celia Mueller Grandjean; Thomas Sasse; Martine Clozel; Oliver Nayler

doi:10.1371/journal.pone.0047662

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Open Access

Peer-reviewed

Research Article

Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

John Gatfield ,

* E-mail: john.gatfield@actelion.com

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Celia Mueller Grandjean,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Thomas Sasse,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Martine Clozel,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Oliver Nayler

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯

Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

John Gatfield,
Celia Mueller Grandjean,
Thomas Sasse,
Martine Clozel,
Oliver Nayler

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0047662

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Media coverage for this article

Posted by PLOS_ONE_Group on 25 Oct 2013 at 22:45 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Market Watch
Title: “Actelion receives US FDA approval of Opsumit (macitentan) for the treatment of pulmonary arterial hypertension - MarketWatch”
http://www.marketwatch.co...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE STAFF

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Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

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Media coverage for this article

Posted by PLOS_ONE_Group on 25 Oct 2013 at 22:45 GMT